Retinal Dehydrogenase 1 (ALDH1A1) Antibody
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Description
ALDH1A1 Antibody is a Rabbit Polyclonal against ALDH1A1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Retinal Dehydrogenase 1 (ALDH1A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00352 |
| Alias | 3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII |
| Background | Antibody anti-ALDH1A1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.
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