Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) Antibody
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Description
RPA1 Antibody is a Rabbit Polyclonal antibody against RPA1. RPA1 (Replication Protein A 70 kDa DNA-Binding Subunit, 70kDa) is a protein-coding gene. Diseases associated with RPA1 include xeroderma pigmentosum, group a, and werner syndrome. GO annotations related to this gene include chromatin binding and single-stranded DNA binding.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P27694 |
| Gene ID | 6117 |
| NCBI Accession | NP_002936.1 |
| Background | Antibody anti-RPA1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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RPA1 antibody
As part of the heterotrimeric replication protein A complex(RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage(PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response(PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage(PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair(PubMed:7697716). Plays also a role in base excision repair(BER) probably through interaction with UNG(PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance(PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C(RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange(PubMed:19996105).
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Recombinant Human RPA1
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Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) Antibody
RPA1 Antibody is a Rabbit Polyclonal antibody against RPA1. RPA1 (Replication Protein A 70 kDa DNA-Binding Subunit, 70kDa) is a protein-coding gene. Diseases associated with RPA1 include xeroderma pigmentosum, group a, and werner syndrome. GO annotations related to this gene include chromatin binding and single-stranded DNA binding.
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