DNA-Binding Protein RFX5 (RFX5) Antibody
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Description
Regulatory Factor X, 5 (Influences Hla Class Ii Expression) Antibody is a Rabbit Polyclonal antibody against Regulatory Factor X, 5 (Influences Hla Class Ii Expression).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DNA-Binding Protein RFX5 (RFX5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48382 |
| Gene ID | 5993 |
| NCBI Accession | NP_000440.1, NM_000449.3 |
| OMIM | 209920 |
| Background | Antibody anti-RFX5 |
| Status | RUO |
Descripción
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RFX5 antibody
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
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DNA-Binding Protein RFX5 (RFX5) Antibody
RFX5 Antibody is a Rabbit Polyclonal antibody against RFX5. A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
Ver ProductoDNA-Binding Protein RFX5 (RFX5) Antibody
Regulatory Factor X, 5 (Influences Hla Class Ii Expression) Antibody is a Rabbit Polyclonal antibody against Regulatory Factor X, 5 (Influences Hla Class Ii Expression).
Ver Producto