Recombinant Mouse VCAM1

Este producto es parte de VCAM1 - Vascular Cell Adhesion Molecule 1
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935106861
info@markelab.com
name
Recombinant Mouse VCAM1
category
Proteins and Peptides
provider
FineTest
reference
P5046
tested applications
Western Blot,ELISA

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Data sheet

Product specifications

CategoryProteins and Peptides
Immunogen Target25-309
HostE.Coli
OriginMouse
Observed MW31.2 kDa
ExpressionRecombinant
PurityGreater than 95% by SDS-PAGE gel analyses
PurificationHis tag
Size 150μg
Size 2200μg
Size 31mg
FormLyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Tested ApplicationsWestern Blot,ELISA
BufferReconstitute with Sterile distilled water
Availability3-4 weeks
Storage-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
UniProt IDP29533
AliasV-CAM 1,VCAM-1,INCAM-100,CD106
BackgroundProteins VCAM1
StatusRUO
NoteThis product is for research use only.

VCAM1 is a transmembrane glycoprotein and member of the immunoglobulin superfamily that plays a key role in cell adhesion, particularly in leukocyte-endothelial interactions during inflammation VCAM1 is expressed on endothelial cells in response to pro-inflammatory cytokines such as TNF-α and IL-1β where it mediates the adhesion and transmigration of leukocytes, including monocytes and lymphocytes, into inflamed tissues VCAM1 interacts with its ligand VLA-4 (integrin α4β1) to facilitate immune cell recruitment during acute and chronic inflammatory responses VCAM1 is implicated in various diseases including atherosclerosis, where it promotes monocyte adhesion to endothelial cells and contributes to plaque formation Elevated VCAM1 levels are also associated with rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders, where persistent inflammation leads to tissue damage VCAM1 serves as a biomarker for endothelial activation and vascular inflammation, making it a potential target for therapeutic interventions aimed at reducing leukocyte recruitment and chronic inflammation

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