Recombinant Mouse PPAR gamma

Este producto es parte de PPAR - peroxisome proliferator activated receptor
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935106861
info@markelab.com
name
Recombinant Mouse PPAR gamma
category
Proteins and Peptides
provider
FineTest
reference
P5137
tested applications
Western Blot,ELISA

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Data sheet

Product specifications

CategoryProteins and Peptides
Immunogen Target1-505
HostE.Coli
OriginMouse
Observed MW55.4 kDa
ExpressionRecombinant
PurityGreater than 95% by SDS-PAGE gel analyses
PurificationHis tag
Size 150μg
Size 2200μg
Size 31mg
FormLyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Tested ApplicationsWestern Blot,ELISA
BufferReconstitute with Sterile distilled water
Availability3-4 weeks
Storage-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
UniProt IDP37238
AliasGLM1,CIMT1,NR1C3,PPARG1,PPARG2,PPARG5,PPARgamma,Nuclear receptor subfamily 1 group C member 3
BackgroundProteins PPARG
StatusRUO
NoteThis product is for research use only.

Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear receptor that plays a central role in the regulation of glucose and lipid metabolism, adipogenesis, and inflammation PPARG is highly expressed in adipose tissue, where it regulates the differentiation of preadipocytes into mature adipocytes and controls the storage of fatty acids PPARG also modulates the expression of genes involved in insulin sensitivity, glucose homeostasis, and lipid storage, and it is a critical factor in maintaining metabolic balance Dysregulation of PPARG has been associated with a variety of metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease PPARG is a major target for drugs like thiazolidinediones (TZDs), which are used to improve insulin sensitivity in type 2 diabetes However, PPARG activation also influences immune responses and inflammation, and its role in chronic inflammation has linked it to diseases such as atherosclerosis and cancer Modulating PPARG activity offers therapeutic potential for addressing metabolic diseases, inflammatory conditions, and cancer, making it an important target for drug development in multiple areas of medicine

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