Recombinant Mouse PPAR gamma

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935106861
info@markelab.com
name
Recombinant Mouse PPAR gamma
category
Proteins and Peptides
provider
FineTest
reference
P5137
tested applications
Western Blot,ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | 1-505 |
Host | E.Coli |
Origin | Mouse |
Observed MW | 55.4 kDa |
Expression | Recombinant |
Purity | Greater than 95% by SDS-PAGE gel analyses |
Purification | His tag |
Size 1 | 50μg |
Size 2 | 200μg |
Size 3 | 1mg |
Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
Tested Applications | Western Blot,ELISA |
Buffer | Reconstitute with Sterile distilled water |
Availability | 3-4 weeks |
Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
UniProt ID | P37238 |
Alias | GLM1,CIMT1,NR1C3,PPARG1,PPARG2,PPARG5,PPARgamma,Nuclear receptor subfamily 1 group C member 3 |
Background | Proteins PPARG |
Status | RUO |
Note | This product is for research use only. |
Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear receptor that plays a central role in the regulation of glucose and lipid metabolism, adipogenesis, and inflammation PPARG is highly expressed in adipose tissue, where it regulates the differentiation of preadipocytes into mature adipocytes and controls the storage of fatty acids PPARG also modulates the expression of genes involved in insulin sensitivity, glucose homeostasis, and lipid storage, and it is a critical factor in maintaining metabolic balance Dysregulation of PPARG has been associated with a variety of metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease PPARG is a major target for drugs like thiazolidinediones (TZDs), which are used to improve insulin sensitivity in type 2 diabetes However, PPARG activation also influences immune responses and inflammation, and its role in chronic inflammation has linked it to diseases such as atherosclerosis and cancer Modulating PPARG activity offers therapeutic potential for addressing metabolic diseases, inflammatory conditions, and cancer, making it an important target for drug development in multiple areas of medicine
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This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
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