Recombinant Human TNF alpha
proveedor
FineTestreference
P4416Tested Applications
Western Blot，ELISAreactivity
status
RUOclonality
Background
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Background
El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.
Características del producto
category
Proteins and Peptides
origin
Human
host
E.Coli
immunogen target
77-233
host
E.Coli
form
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
tested applications
Western Blot，ELISA
size 1
50μg
size 2
200μg
size 3
1mg
observerd MW
17.2 kDa
expression
Recombinant
purity
Greater than 95% by SDS-PAGE gel analyses
purification
His tag
buffer
Reconstitute with Sterile distilled water
storage
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
or code
TNF
availability
3-4 weeks
alias
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
uniprot id
note
This product is for research use only.
Quizá le pueda interesar
Low Sample Volume Rabbit Tumor Necrosis Factor (TNF) ELISA Kit
proveedor
Abbexareference
abx051164Tested Applications
ELISAreactivity
Rabbitstatus
RUORabbit Tumor Necrosis Factor (TNF) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rabbit Tumor N...
787.5€ (96 tests)
Ver másTumor Necrosis Factor (TNF) Antibody (Biotin)
proveedor
Abbexareference
abx272629Tested Applications
WB, IHC, IF/ICCreactivity
Mousestatus
RUOclonality
PolyclonalTumor Necrosis Factor (TNF) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Tumor Necrosi...
287.5€ (200 µl)
Ver másRabbit Tumor Necrosis Factor (TNF) CLIA Kit
proveedor
Abbexareference
abx491103Tested Applications
CLIAreactivity
Rabbitstatus
RUORabbit Tumor Necrosis Factor (TNF) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (C...
812.5€ (96 tests)
Ver más