TNF Antibody is a Rabbit Polyclonal antibody against TNF. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Tumor Necrosis Factor (TNF)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TNF
No
Shipped within 5-10 working days.
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
NP_000585.2
This product is for research use only.
TNF-α(71-82) is a peptide.
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