Tumor Necrosis Factor (TNF) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Tumor Necrosis Factor (TNF) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000662
tested applications
IHC, IF/ICC
Description
TNF Antibody is a Rabbit Polyclonal antibody against TNF. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor (TNF) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01375 |
| Gene ID | 7124 |
| NCBI Accession | NP_000585.2 |
| OMIM | 191160 |
| Alias | TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin |
| Background | Antibody anti-TNF |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Tumor Necrosis Factor (TNF) is a versatile cytokine involvedl in numerous physiological and pathological processes. It holds a critical role in modulating immune responses, inflammation, and apoptosis. While predominantly produced by activated macrophages, TNF can also originate from various cell types like lymphocytes, mast cells, endothelial cells, and fibroblasts. Two well-known forms of TNF are TNF-alpha and TNF-beta, also referred to as lymphotoxin-alpha. TNF-alpha, being extensively studied, exists in both soluble and membrane-bound forms, both capable of initiating biological responses by binding to their respective receptors. TNF signaling operates through two receptors: TNFR1 and TNFR2. TNFR1 is ubiquitously expressed across cell types, whereas TNFR2 is primarily found in endothelial, epithelial, and certain immune cells. TNFR1 signaling typically triggers pro-inflammatory and apoptotic responses, while TNFR2 signaling exhibits anti-inflammatory properties and fosters cell proliferation. In autoimmune disease treatment, suppressing TNFR1 signaling has proved significant, whereas TNFR2 signaling supports wound healing.The primary function of TNF lies in regulating immune cells
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