Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT2 participates in regulating microtubule acetylation, controlling myelination in the central and peripheral nervous systems, and influencing gluconeogenesis.
Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT2 participa en la regulación de la acetilación de los microtúbulos, controla la mielinización en los sistemas nerviosos central y periférico e influye en la gluconeogénesis.
Proteins and Peptides
Human
E.Coli
1-389
E.Coli
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Western Blot,ELISA
50μg
200μg
1mg
42.7 kDa
Recombinant
Greater than 95% by SDS-PAGE gel analyses
His tag
Reconstitute with Sterile distilled water
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
SIRT2
3-4 weeks
SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2
This product is for research use only.
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