Recombinant Human RAB7

Background

RAB7A, member RAS oncogene family (RAB7A) is a GTPase that plays a central role in regulating late endosomal and lysosomal trafficking, which is crucial for maintaining cellular homeostasis and protein degradation RAB7A is involved in controlling the movement of vesicles from early endosomes to late endosomes and from late endosomes to lysosomes, where materials are processed and degraded It also regulates autophagy, a cellular process responsible for the recycling of damaged organelles and proteins RAB7A’s involvement in these pathways helps control cellular signaling, immune responses, and tissue homeostasis Additionally, RAB7A has been shown to play a role in regulating the transport of key receptors involved in cell survival and immune responses Mutations or dysregulation of RAB7A are linked to several diseases, including neurodegenerative disorders, where defective vesicular transport impairs the clearance of cellular waste and leads to the accumulation of toxic substances Understanding RAB7A’s role in vesicular trafficking is critical for developing potential therapies for neurodegenerative diseases and cancer, where altered cellular transport processes contribute to disease pathogenesis