Recombinant Human PAX6
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935106861
info@markelab.com
name
Recombinant Human PAX6
category
Proteins and Peptides
provider
FineTest
reference
P2402
tested applications
Western Blot, ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 130-283 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 38.4 kDa |
| Expression | Recombinant |
| Purity | Greater than 75% by SDS-PAGE gel analyses |
| Purification | IF2DI tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Tested Applications | Western Blot, ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 7 days |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | P26367 |
| Alias | AN,AN1,AN2,ASGD5,D11S812E,FVH1,MGDA,WAGR,Aniridia type II protein,Oculorhombin |
| Background | Proteins PAX6 |
| Status | RUO |
| Note | This product is for research use only. |
PAX6 is a highly conserved transcription factor critical for the development of the eyes, central nervous system, and endocrine pancreas. It regulates the expression of genes involved in eye morphogenesis, lens formation, and neuronal differentiation. PAX6 acts as a master regulator of ocular development, with its mutations causing congenital eye disorders such as aniridia, Peters anomaly, and microphthalmia. It also plays a role in brain patterning, where it contributes to neurogenesis and cortical layer formation. PAX6 is essential for pancreatic β-cell development, where it influences insulin production and glucose regulation. Dysregulation of PAX6 has been linked to neurological disorders and metabolic dysfunction. Knockout studies in mice reveal severe ocular malformations, brain developmental defects, and pancreatic abnormalities, highlighting its critical role in tissue differentiation, organogenesis, and cell fate determination during embryonic development.
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Recombinant Human PAX6
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