Paired Box Protein Pax-6 (PAX6) Antibody
559€ (100 µl)
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935106861
info@markelab.com
name
Paired Box Protein Pax-6 (PAX6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025233
tested applications
ELISA, WB, IF/ICC
Description
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq]. This antibody is supplied as crude ascites.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-6 (PAX6) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/16000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM Kappa |
| Purification | Unpurified crude ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P26367 |
| Alias | AN,AN1,AN2,ASGD5,D11S812E,FVH1,MGDA,WAGR,Aniridia type II protein,Oculorhombin |
| Background | Antibody anti-PAX6 |
| Status | RUO |
Descripción
PAX6 is a highly conserved transcription factor critical for the development of the eyes, central nervous system, and endocrine pancreas. It regulates the expression of genes involved in eye morphogenesis, lens formation, and neuronal differentiation. PAX6 acts as a master regulator of ocular development, with its mutations causing congenital eye disorders such as aniridia, Peters anomaly, and microphthalmia. It also plays a role in brain patterning, where it contributes to neurogenesis and cortical layer formation. PAX6 is essential for pancreatic β-cell development, where it influences insulin production and glucose regulation. Dysregulation of PAX6 has been linked to neurological disorders and metabolic dysfunction. Knockout studies in mice reveal severe ocular malformations, brain developmental defects, and pancreatic abnormalities, highlighting its critical role in tissue differentiation, organogenesis, and cell fate determination during embryonic development.
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