Recombinant Human Neuroserpin
proveedor
FineTestreference
P6488Tested Applications
Western Blot,ELISAreactivity
status
RUOclonality
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL)Neuroserpin is a protein that in humans is encoded by the SERPINI1 gen. Neuroserpin inhibits the activity of an enzyme called tissue plasminogen activator (tPA), which plays a role in cell movement (migration), blood clotting, and inflammation.
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle central reactivo (RCL). La neuroserpina es una proteína que en los humanos está codificada por SERPINI1. gen. La neuroserpina inhibe la actividad de una enzima llamada activador del plasminógeno tisular (tPA), que desempeña un papel en el movimiento celular (migración), la coagulación sanguínea y la inflamación.
Características del producto
category
Proteins and Peptides
origin
Human
host
E.Coli
immunogen target
17-410
host
E.Coli
form
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
tested applications
Western Blot,ELISA
size 1
50μg
size 2
200μg
size 3
1mg
observerd MW
43.2 kDa
expression
Recombinant
purity
Greater than 95% by SDS-PAGE gel analyses
purification
His tag
buffer
Reconstitute with Sterile distilled water
storage
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
or code
SERPINI1
availability
3-4 weeks
alias
PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1
uniprot id
note
This product is for research use only.
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