Recombinant Human Neuroserpin

Recombinant Human Neuroserpin

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935106861

info@markelab.com

Precio

Precio a consultar

proveedor

FineTest

reference

P6488

Tested Applications

Western Blot,ELISA

reactivity

status

RUO

clonality

Background

Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL)Neuroserpin is a protein that in humans is encoded by the SERPINI1 gen. Neuroserpin inhibits the activity of an enzyme called tissue plasminogen activator (tPA), which plays a role in cell movement (migration), blood clotting, and inflammation.

Background

Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle central reactivo (RCL). La neuroserpina es una proteína que en los humanos está codificada por SERPINI1. gen. La neuroserpina inhibe la actividad de una enzima llamada activador del plasminógeno tisular (tPA), que desempeña un papel en el movimiento celular (migración), la coagulación sanguínea y la inflamación.

Características del producto

category

Proteins and Peptides


origin

Human


host

E.Coli


immunogen target

17-410


host

E.Coli


form

Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4


tested applications

Western Blot,ELISA


size 1

50μg


size 2

200μg


size 3

1mg


observerd MW

43.2 kDa


expression

Recombinant


purity

Greater than 95% by SDS-PAGE gel analyses


purification

His tag


buffer

Reconstitute with Sterile distilled water


storage

-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution


or code

SERPINI1


availability

3-4 weeks


alias

PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1


note

This product is for research use only.


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