Neuroserpin (SERPINI1) Antibody
637€ (100 µl)
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935106861
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name
Neuroserpin (SERPINI1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx115478
tested applications
ELISA, WB
Description
Serpin Peptidase Inhibitor, Clade I (Neuroserpin), Member 1 Antibody is a Rabbit Polyclonal antibody against Serpin Peptidase Inhibitor, Clade I (Neuroserpin), Member 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuroserpin (SERPINI1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99574 |
| Gene ID | 5274 |
| OMIM | 602445 |
| Alias | PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1 |
| Background | Antibody anti-SERPINI1 |
| Status | RUO |
Descripción
SERPINI1 (serpin family I member 1) is a gene encoding the neuroserpin protein, a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins, neuroserpin is primarily expressed in the central nervous system, where it plays a critical role in regulating proteolytic activity, particularly by inhibiting tissue-type plasminogen activator (tPA). The balance between neuroserpin and tPA is crucial for neural development, synaptic plasticity, and maintaining the integrity of neuronal tissues. SERPINI1 mutations are associated with certain neurodegenerative diseases, notably familial encephalopathy with neuroserpin inclusion bodies (FENIB), a condition characterized by the accumulation of misfolded neuroserpin proteins in neurons. This leads to neurodegeneration, progressive cognitive decline, and other neurological impairments.
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