Recombinant Human MAGOH

Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Recombinant Human MAGOH
category
Proteins and Peptides
provider
FineTest
reference
P8242
tested applications
Western Blot, ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

CategoryProteins and Peptides
Immunogen Target1-146
HostE.Coli
OriginHuman
Observed MW37.8 kDa
ExpressionRecombinant
PurityGreater than 80% by SDS-PAGE gel analyses
PurificationN-terminal His-IF2DI Tag
Size 150μg
Size 2200μg
Size 31mg
FormLyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.06% proclin, pH7.4
Tested ApplicationsWestern Blot, ELISA
BufferCentrifuge the vial at 10,000 rpm for 1 minute, reconstitute at 500 μg/ml in Reconstitute with Sterile distilled water
Availability3-4 weeks
Storage-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
UniProt IDP61326
AliasMAGOH, MAGOHA, Protein mago nashi homolog
BackgroundProteins MAGOH
StatusRUO
NoteThis product is for research use only.

Related Products

FNab04954

anti- MAGOH antibody

Core component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay(NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Ver Producto
P8242

Recombinant Human MAGOH

Ver Producto
abx004643

Protein Mago Nashi Homolog (MAGOH) Antibody

MAGOH Antibody is a Rabbit Monoclonal antibody against MAGOH. Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

Ver Producto