Recombinant Human DCC

Este producto es parte de DCC netrin 1 receptor
Recombinant Human DCC

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Proteins DCC

proveedor

FineTest

reference

P5191

Tested Applications

Western Blot,ELISA

reactivity

status

RUO

clonality


Background

The DCC (Deleted in Colorectal Carcinoma) receptor is a key transmembrane protein that functions as a receptor for netrin-1, a secreted guidance cue that directs axon growth and neuronal migration during embryonic development. DCC is essential for axon guidance, mediating attraction of neuronal growth cones toward sources of netrin-1 in the developing nervous system. Structurally, DCC contains immunoglobulin-like and fibronectin-type III domains in its extracellular region, enabling interaction with netrin-1, and intracellular domains that recruit signaling proteins, such as the Src family kinases, to transduce guidance signals. Beyond its role in neural development, DCC is also implicated in maintaining tissue homeostasis, acting as a dependence receptor to induce apoptosis in the absence of netrin-1. Mutations or loss of DCC expression have been associated with colorectal cancer and other malignancies, highlighting its role as a tumor suppressor. DCC is highly expressed in the developing central nervous system, particularly in commissural neurons, and its functions in axon guidance are critical for establishing proper neural circuitry.

Características del producto

category

Proteins and Peptides


origin

Human


host

E.Coli


immunogen target

841-941


host

E.Coli


form

Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4


tested applications

Western Blot,ELISA


size 1

50μg


size 2

200μg


size 3

1mg


observerd MW

11 kDa


expression

Recombinant


purity

Greater than 95% by SDS-PAGE gel analyses


purification

His tag


buffer

Reconstitute with Sterile distilled water


storage

-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution


or code

DCC


availability

3-4 weeks


alias

CRC18,CRCR1,MRMV1,HGPPS2,IGDCC1,NTN1R1,Tumor suppressor protein DCC,Immunoglobulin superfamily DCC subclass member 1,Colorectal cancer suppressor


note

This product is for research use only.


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