Recombinant Human DCC
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935106861
info@markelab.com
Precio
Precio a consultar
Proteins DCC
proveedor
FineTestreference
P5191Tested Applications
Western Blot,ELISAreactivity
status
RUOclonality
Background
The DCC (Deleted in Colorectal Carcinoma) receptor is a key transmembrane protein that functions as a receptor for netrin-1, a secreted guidance cue that directs axon growth and neuronal migration during embryonic development. DCC is essential for axon guidance, mediating attraction of neuronal growth cones toward sources of netrin-1 in the developing nervous system. Structurally, DCC contains immunoglobulin-like and fibronectin-type III domains in its extracellular region, enabling interaction with netrin-1, and intracellular domains that recruit signaling proteins, such as the Src family kinases, to transduce guidance signals. Beyond its role in neural development, DCC is also implicated in maintaining tissue homeostasis, acting as a dependence receptor to induce apoptosis in the absence of netrin-1. Mutations or loss of DCC expression have been associated with colorectal cancer and other malignancies, highlighting its role as a tumor suppressor. DCC is highly expressed in the developing central nervous system, particularly in commissural neurons, and its functions in axon guidance are critical for establishing proper neural circuitry.
Características del producto
category
Proteins and Peptides
origin
Human
host
E.Coli
immunogen target
841-941
host
E.Coli
form
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
tested applications
Western Blot,ELISA
size 1
50μg
size 2
200μg
size 3
1mg
observerd MW
11 kDa
expression
Recombinant
purity
Greater than 95% by SDS-PAGE gel analyses
purification
His tag
buffer
Reconstitute with Sterile distilled water
storage
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
or code
DCC
availability
3-4 weeks
alias
CRC18,CRCR1,MRMV1,HGPPS2,IGDCC1,NTN1R1,Tumor suppressor protein DCC,Immunoglobulin superfamily DCC subclass member 1,Colorectal cancer suppressor
uniprot id
note
This product is for research use only.
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