Recombinant Human ANP

Este producto es parte de ANP - Atrial Natriuretic Peptide
Recombinant Human ANP

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Proteins ANP

proveedor

FineTest

reference

P1932

Tested Applications

Western Blot, ELISA

reactivity

status

RUO

clonality


Background

Atrial Natriuretic Peptide (ANP) is a hormone secreted primarily by cardiac atrial myocytes in response to increased blood volume or pressure, playing a pivotal role in cardiovascular and fluid homeostasis. ANP exerts its effects by binding to natriuretic peptide receptor-A (NPR-A), leading to increased intracellular cyclic guanosine monophosphate (cGMP) levels, which mediate vasodilation and natriuresis. This hormone reduces systemic vascular resistance and promotes sodium and water excretion in the kidneys, thereby lowering blood pressure and blood volume. ANP is also a critical regulator of the renin-angiotensin-aldosterone system (RAAS), counteracting the effects of angiotensin II and aldosterone to prevent fluid overload. Clinically, elevated ANP levels are observed in conditions like heart failure and atrial fibrillation, serving as a biomarker for these diseases. Therapeutically, recombinant ANP and analogs are being explored for their potential in treating acute decompensated heart failure and hypertension. Research also highlights ANP’s role in protecting against cardiac hypertrophy, fibrosis, and remodeling, emphasizing its broader significance in cardiovascular health and disease management.

Características del producto

category

Proteins and Peptides


origin

Human


host

E.Coli


immunogen target

26-123


host

E.Coli


form

Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4


tested applications

Western Blot, ELISA


size 1

50μg


size 2

200μg


size 3

1mg


observerd MW

31.3 kDa


expression

Recombinant


purity

Greater than 95% by SDS-PAGE gel analyses


purification

IF2DI tag


buffer

Reconstitute with Sterile distilled water


storage

-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution


or code

ANP


availability

7 days


alias

NPPA,ANF,ANP,ATFB6,Atrial natriuretic factor


note

This product is for research use only.


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