Recombinant Human ANGPTL6

Background

ANGPTL6, also known as angiopoietin-related growth factor (AGF), is a secreted protein involved in angiogenesis, wound healing, and metabolic regulation. ANGPTL6 promotes endothelial cell proliferation and migration, enhancing angiogenesis and contributing to tissue regeneration and repair. It is upregulated in response to tissue injury and functions to accelerate wound healing by improving vascularization and dermal recovery. ANGPTL6 also plays an important role in metabolic homeostasis by enhancing insulin sensitivity and energy expenditure, which protects against obesity and insulin resistance. Dysregulation of ANGPTL6 has been associated with metabolic syndrome, cardiovascular diseases, and diabetes, where it may serve as a compensatory factor for impaired energy metabolism. Additionally, ANGPTL6 is implicated in cancer progression by modulating angiogenesis and tumor cell proliferation. Its dual role in tissue repair and metabolic regulation highlights ANGPTL6 as a potential therapeutic target for chronic metabolic diseases, wound healing, and cancer.