Recombinant Human AKAP13
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935106861
info@markelab.com
name
Recombinant Human AKAP13
category
Proteins and Peptides
provider
FineTest
reference
P5693
tested applications
Western Blot,ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 2-161 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 17.5 kDa |
| Expression | Recombinant |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Purification | His tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Tested Applications | Western Blot,ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 3-4 weeks |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | Q12802 |
| Alias | AKAP-13,AKAP-Lbc,ARHGEF13 |
| Background | Proteins AKAP13 |
| Status | RUO |
| Note | This product is for research use only. |
AKAP13, also known as BRX (BRE-1-related exchange factor), is a scaffold protein that not only binds PKA but also acts as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, such as RhoA. AKAP13 plays a critical role in the regulation of cytoskeletal dynamics, cell migration, and proliferation through crosstalk between PKA and Rho signaling pathways. Its Rho-GEF activity regulates actin cytoskeleton organization, influencing processes like adhesion, morphogenesis, and stress fiber formation. AKAP13 is a key regulator of cardiac hypertrophy and heart development, where it mediates PKA and RhoA signaling in cardiomyocytes under mechanical stress. Dysregulation of AKAP13 has been implicated in cancer progression, as it promotes tumor cell motility and invasion through enhanced cytoskeletal reorganization and focal adhesion dynamics. AKAP13 also interacts with steroid hormone receptors, such as estrogen and glucocorticoid receptors, linking it to transcriptional regulation in hormonal signaling pathways. Studies show that AKAP13 mutations are associated with developmental disorders, cardiac anomalies, and hormone-driven cancers.
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