Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody (APC)
637€ (100 µg)
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935106861
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name
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx442732
tested applications
WB, IF/ICC
Description
LAR/PTPRF Antibody is a Mouse Monoclonal against LAR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG2a |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.1% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10586 |
| Gene ID | 5792 |
| NCBI Accession | NP_002831.2. |
| Alias | LAR,BNAH2,Leukocyte common antigen related,Receptor-type tyrosine-protein phosphatase F |
| Background | Antibody anti-PTPRF |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PTPRF, also known as leukocyte common antigen-related (LAR) protein, is a receptor-like protein tyrosine phosphatase involved in cell-cell adhesion, neuronal development, and tissue organization. Structurally, PTPRF contains extracellular immunoglobulin-like (Ig) domains, fibronectin type III domains, a single transmembrane region, and two intracellular phosphatase domains, where the first exhibits enzymatic activity. PTPRF plays a critical role in synaptic formation, axonal guidance, and neuronal differentiation through interactions with ligands like netrin-G ligands and heparan sulfate proteoglycans. It regulates focal adhesion and cytoskeletal organization by interacting with intracellular proteins such as liprin-α. Mutations or dysregulation of PTPRF have been implicated in cancers, insulin resistance, and neurological disorders, including intellectual disability and autism.
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