Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody (APC)
429€ (0.1 mg)
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Name
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140641
Tested Applications
FCM
Description
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody (APC) is a mouse monoclonal antibody against Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Assay Type | Concentration: 0.1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 |
| Clone ID | Y964 |
| Purification | The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | G1UI20 |
| Gene ID | 5792 |
| Alias | LAR,BNAH2,Leukocyte common antigen related,Receptor-type tyrosine-protein phosphatase F |
| Background | Antibody anti-PTPRF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRF, also known as leukocyte common antigen-related (LAR) protein, is a receptor-like protein tyrosine phosphatase involved in cell-cell adhesion, neuronal development, and tissue organization. Structurally, PTPRF contains extracellular immunoglobulin-like (Ig) domains, fibronectin type III domains, a single transmembrane region, and two intracellular phosphatase domains, where the first exhibits enzymatic activity. PTPRF plays a critical role in synaptic formation, axonal guidance, and neuronal differentiation through interactions with ligands like netrin-G ligands and heparan sulfate proteoglycans. It regulates focal adhesion and cytoskeletal organization by interacting with intracellular proteins such as liprin-α. Mutations or dysregulation of PTPRF have been implicated in cancers, insulin resistance, and neurological disorders, including intellectual disability and autism.
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