Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240301
tested applications
ELISA, WB
Description
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody is a Mouse Monoclonal antibody for the detection of PTPRF.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10586 |
| Gene ID | 5792 |
| NCBI Accession | NP_569707.2 |
| Alias | LAR,BNAH2,Leukocyte common antigen related,Receptor-type tyrosine-protein phosphatase F |
| Background | Antibody anti-PTPRF |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
PTPRF, also known as leukocyte common antigen-related (LAR) protein, is a receptor-like protein tyrosine phosphatase involved in cell-cell adhesion, neuronal development, and tissue organization. Structurally, PTPRF contains extracellular immunoglobulin-like (Ig) domains, fibronectin type III domains, a single transmembrane region, and two intracellular phosphatase domains, where the first exhibits enzymatic activity. PTPRF plays a critical role in synaptic formation, axonal guidance, and neuronal differentiation through interactions with ligands like netrin-G ligands and heparan sulfate proteoglycans. It regulates focal adhesion and cytoskeletal organization by interacting with intracellular proteins such as liprin-α. Mutations or dysregulation of PTPRF have been implicated in cancers, insulin resistance, and neurological disorders, including intellectual disability and autism.
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