Rat Urotensin 2 Receptor (UTS2R) Protein
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Description
Rat Urotensin 2 Receptor (UTS2R) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Urotensin 2 Receptor (UTS2R) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | UTS2R,GPR14,UII-R1,UTR2,G protein-coupled receptor 14,urotensin II receptor,SENR,UR-2-R,UTR |
| Background | Protein UTS2R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
UTS2R is a G protein-coupled receptor activated by urotensin 2 (U-2), a potent vasoconstrictor peptide involved in regulating cardiovascular function, particularly blood pressure and vascular tone. UTS2R couples to Gq proteins, activating phospholipase C (PLC) and increasing intracellular calcium levels, leading to vasoconstriction and modulation of smooth muscle contraction. Urotensin 2 is a critical mediator in the regulation of blood vessel function, and UTS2R’s expression in the vasculature suggests that it plays an important role in blood pressure homeostasis and vascular remodeling. Dysregulation of UTS2R signaling is associated with cardiovascular diseases such as hypertension and heart failure. Antagonists of UTS2R are being explored for their therapeutic potential in treating conditions related to excessive vasoconstriction, including pulmonary arterial hypertension and atherosclerosis.
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