Rat Transmembrane Emp24 Domain-Containing Protein 3 (TMED3) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Transmembrane Emp24 Domain-Containing Protein 3 (TMED3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx550415
tested applications
ELISA
Description
Rat Transmembrane emp24 domain-containing protein 3 ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Transmembrane emp24 domain-containing protein 3 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 3 (TMED3) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | C15orf22, P24B, p24g4, p24gamma4, p26,p24 family protein gamma-4,p24gamma4 p26 |
| Background | Elisa kits for TMED3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TMED3 is a member of the p24 protein family, functioning as a cargo receptor in the early secretory pathway that mediates protein transport between the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. It regulates the selection and packaging of specific cargo proteins into COPII-coated vesicles for export from the ER and coordinates vesicle retrieval via COPI machinery. TMED3 plays an important role in maintaining Golgi structure and the balance of protein flux through the secretory system. Beyond its trafficking role, TMED3 is implicated in Wnt/β-catenin signaling, where it modulates receptor localization and pathway activation critical for cell proliferation, differentiation, and development. Dysregulation of TMED3 contributes to cancers, including colorectal and hepatocellular carcinoma, where altered protein trafficking enhances oncogenic signaling. Knockdown studies reveal impaired vesicular transport, Golgi disorganization, and disrupted Wnt signaling, highlighting its essential role in secretory trafficking, Golgi homeostasis, and signaling regulation.
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