Rat Transforming Growth Factor Beta 2 (TGFb2) Protein

Este producto es parte de TGFB- Transforming Growth Factor Beta
Rat Transforming Growth Factor Beta 2 (TGFb2) Protein

Pida mas información

935106861

info@markelab.com

Precio

260€ (10 µg)

Protein TGFB2

proveedor

Abbexa

reference

abx069430

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Rat Transforming Growth Factor Beta 2 (TGFb2) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

TGFB2 is a member of the TGF-β cytokine family, which regulates a wide range of cellular processes, including proliferation, differentiation, migration, apoptosis, and immune suppression. TGFB2 is critically involved in embryogenesis, particularly in the development of the heart, lungs, and central nervous system, as well as in tissue homeostasis and repair. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression and cellular responses to environmental stimuli. TGFB2 plays an essential role in immune regulation, where it suppresses inflammation and promotes tolerance by inducing regulatory T cell (Treg) development. Dysregulation of TGFB2 is implicated in developmental disorders, fibrosis, and tumor progression, where it drives epithelial-mesenchymal transition (EMT) and facilitates immune evasion. Knockout studies show severe developmental defects, including cardiac abnormalities, craniofacial malformations, and impaired organogenesis, underscoring TGFB2’s importance in tissue development, immune modulation, and homeostatic maintenance.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Transforming Growth Factor Beta 2 (TGFb2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 13.9 kDa Observed MW (SDS-PAGE): 12 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala331-Ser442 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TGFB2


dry ice

No


availability

Shipped within 5-7 working days.


alias

G-TSF,LDS4,TGF-beta2,Cetermin,Glioblastoma-derived T-cell suppressor factor 


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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