Rat Transforming Growth Factor Beta 2 (TGFb2) Protein
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935106861
info@markelab.com
Precio
260€ (10 µg)
Protein TGFB2
proveedor
Abbexareference
abx069430Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Transforming Growth Factor Beta 2 (TGFb2) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
TGFB2 is a member of the TGF-β cytokine family, which regulates a wide range of cellular processes, including proliferation, differentiation, migration, apoptosis, and immune suppression. TGFB2 is critically involved in embryogenesis, particularly in the development of the heart, lungs, and central nervous system, as well as in tissue homeostasis and repair. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression and cellular responses to environmental stimuli. TGFB2 plays an essential role in immune regulation, where it suppresses inflammation and promotes tolerance by inducing regulatory T cell (Treg) development. Dysregulation of TGFB2 is implicated in developmental disorders, fibrosis, and tumor progression, where it drives epithelial-mesenchymal transition (EMT) and facilitates immune evasion. Knockout studies show severe developmental defects, including cardiac abnormalities, craniofacial malformations, and impaired organogenesis, underscoring TGFB2’s importance in tissue development, immune modulation, and homeostatic maintenance.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Transforming Growth Factor Beta 2 (TGFb2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 13.9 kDa Observed MW (SDS-PAGE): 12 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala331-Ser442 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TGFB2
dry ice
No
availability
Shipped within 5-7 working days.
alias
G-TSF,LDS4,TGF-beta2,Cetermin,Glioblastoma-derived T-cell suppressor factor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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