Rat Sphingosine 1 Phosphate Receptor 3 (S1PR3) Protein

1872€ (1 mg)
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935106861
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name
Rat Sphingosine 1 Phosphate Receptor 3 (S1PR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655118
tested applications
WB, SDS-PAGE
Description
Rat Sphingosine 1 Phosphate Receptor 3 (S1PR3) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Sphingosine 1 Phosphate Receptor 3 (S1PR3) |
Host | E. coli |
Origin | Rat |
Conjugation | Unconjugated |
Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 1 mg |
Size 2 | 5 mg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 1-2 months. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | S1PR3,C9orf108,C9orf47,EDG-3,EDG3,LPB3,S1P3,endothelial differentiation G protein-coupled receptor 3 |
Background | Protein S1PR3 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
S1PR3 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), widely expressed in endothelial cells, smooth muscle cells, and immune cells. It couples to multiple G proteins (Gq, Gi, and G12/13), activating signaling pathways such as PI3K/Akt, MAPK, and Rho/ROCK. S1PR3 regulates vascular tone, endothelial barrier integrity, and smooth muscle contraction, contributing to blood flow regulation and vascular development. It also influences immune cell migration, inflammatory responses, and cardiac function. In the cardiovascular system, S1PR3 is essential for vasodilation and cardioprotection. Dysregulation of S1PR3 has been associated with chronic inflammation, cardiovascular diseases, and cancer progression. In tumor biology, S1PR3 promotes angiogenesis, metastasis, and immune cell infiltration into the tumor microenvironment. Therapeutically, targeting S1PR3 is being explored for its potential to regulate vascular inflammation, immune responses, and cancer metastasis, making it a promising target in inflammatory and cardiovascular diseases.
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