Rat Sirtuin 1 (SIRT1) Protein
234€ (10 µg)
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935106861
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name
Rat Sirtuin 1 (SIRT1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167597
tested applications
WB, SDS-PAGE
Description
Rat Sirtuin 1 Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Sirtuin 1 (SIRT1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys238-Ala482 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A0A0G2JZ79 |
| NCBI Accession | 149043900 |
| Alias | SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1 |
| Background | Protein SIRT1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
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