Rat Sirtuin 1 (SIRT1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein SIRT1
proveedor
Abbexareference
abx167597Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Sirtuin 1 Protein is a recombinant Rat protein expressed in E. coli.
Background
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Sirtuin 1 (SIRT1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys238-Ala482 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SIRT1
dry ice
No
availability
Shipped within 5-7 working days.
alias
SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1
NCBI accession
149043900
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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