Rat Serpin A12 (SERPINA12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Serpin A12 (SERPINA12) concentrations in serum, plasma and other biological fluids.
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL.). SERPINA12, a 47 kDa protease inhibitor from the adipokine family, has insulin-sensitizing properties. Its treatment in obese and insulin-resistant mice reduces insulin resistance gene expression in white adipose tissue and improves carbohydrate resistance.
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINA12, un inhibidor de la proteasa de 47 kDa de la familia de las adipocinas, tiene propiedades sensibilizadoras a la insulina. Su tratamiento en ratones obesos y resistentes a la insulina reduce la expresión del gen de resistencia a la insulina en el tejido adiposo blanco y mejora la resistencia a los carbohidratos.
ELISA Kits
Serpin A12 (SERPINA12)
Rat
93.75 pg/ml - 6000 pg/ml
56.25 pg/ml
Sandwich
Quantitative
Colorimetric
Serum,Plasma,Other biological fluids
96 tests
Serpin A12,OL-64,Visceral adipose tissue-derived serine protease inhibitor,Vaspin,Visceral adipose-specific serpin
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
SERPINA12
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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