Rat Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein
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935106861
info@markelab.com
Precio
1312.5€ (200 µg)
Protein ACVRL1
proveedor
Abbexareference
abx692731Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat ALK-1 Protein is a recombinant protein from Rat produced in HEK293 Cells. A synthetic DNA sequence encoding the rat ACVRL1 (NP_071886.1) extracellular domain (Met 1-Ala 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Background
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
Características del producto
category
Proteins and Peptides
origin
Rat
host
HEK293 cells
immunogen target
ALK-1
host
HEK293 cells
tested applications
SDS-PAGE
size 1
200 µg
expression
Recombinant
purity
> 90% (SDS-PAGE)
buffer
Lyophilized from sterile PBS, pH 7.4.
storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
or code
ACVRL1
dry ice
No
availability
Shipped within 5-15 working days.
alias
Activin receptor-like kinase 1,ALK-1,SKR3
NCBI accession
NP_071886.1
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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