Rat Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for F2RL2
proveedor
Abbexareference
abx391141Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat F2RL2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Proteinase-Activated Receptor 3 (F2RL2), also known as PAR3, is another member of the PAR family of receptors. It is primarily expressed in platelets, endothelial cells, and the gastrointestinal tract. F2RL2 is activated by thrombin, which cleaves the receptor to reveal a tethered ligand that activates intracellular signaling. Unlike other PARs, F2RL2 acts in concert with F2RL1 (PAR2) to modulate thrombin-induced platelet activation and coagulation. F2RL2 couples to Gi and Gq proteins, triggering a variety of signaling events such as platelet aggregation, smooth muscle contraction, and endothelial cell activation. Its primary role is in regulating hemostasis and thrombus formation, particularly during tissue injury or inflammation. Dysregulation of F2RL2 signaling can contribute to thrombosis, atherosclerosis, and ischemic conditions. Targeting F2RL2 offers therapeutic potential in cardiovascular diseases, particularly those involving abnormal platelet activation and clot formation, by preventing excessive thrombosis without impairing normal wound healing.
Características del producto
category
ELISA Kits
immunogen target
Proteinase-Activated Receptor 3 (F2RL2)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
F2RL2,coagulation factor II receptor-like 2,protease-activated receptor 3,thrombin receptor-like 2,PAR-3,PAR3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
F2RL2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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