Rat Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit

Este producto es parte de F2R - Proteinase-Activated Receptor
Rat Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit

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935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for F2RL2

proveedor

Abbexa

reference

abx391141

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat F2RL2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Proteinase-Activated Receptor 3 (F2RL2), also known as PAR3, is another member of the PAR family of receptors. It is primarily expressed in platelets, endothelial cells, and the gastrointestinal tract. F2RL2 is activated by thrombin, which cleaves the receptor to reveal a tethered ligand that activates intracellular signaling. Unlike other PARs, F2RL2 acts in concert with F2RL1 (PAR2) to modulate thrombin-induced platelet activation and coagulation. F2RL2 couples to Gi and Gq proteins, triggering a variety of signaling events such as platelet aggregation, smooth muscle contraction, and endothelial cell activation. Its primary role is in regulating hemostasis and thrombus formation, particularly during tissue injury or inflammation. Dysregulation of F2RL2 signaling can contribute to thrombosis, atherosclerosis, and ischemic conditions. Targeting F2RL2 offers therapeutic potential in cardiovascular diseases, particularly those involving abnormal platelet activation and clot formation, by preventing excessive thrombosis without impairing normal wound healing.

Características del producto

category

ELISA Kits


immunogen target

Proteinase-Activated Receptor 3 (F2RL2)


reactivity

Rat


test range

78 pg/ml - 5000 pg/ml


sensitivity

< 46.9 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

F2RL2,coagulation factor II receptor-like 2,protease-activated receptor 3,thrombin receptor-like 2,PAR-3,PAR3


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

F2RL2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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