Rat Prostaglandin E Synthase, Microsomal (PTGES) Protein
208€ (10 µg)
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name
Rat Prostaglandin E Synthase, Microsomal (PTGES) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654821
tested applications
WB, SDS-PAGE
Description
Rat Prostaglandin E Synthase, Microsomal (PTGES) Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Prostaglandin E Synthase, Microsomal (PTGES) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 14.7 kDa Observed MW (SDS-PAGE): 16 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | MGST1L1,MPGES1,PGES,PIG12,Microsomal prostaglandin E synthase 1,p53-induced gene 12 protein,PP1294,MGST-IV,MGST1L1,TP53I12;,mPGES-1,MGST1-L1 |
| Background | Protein PTGES |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Prostaglandin E synthase (PTGES) is an inducible enzyme that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a bioactive lipid mediator involved in a wide range of physiological and pathological processes, including inflammation, fever, pain perception, and tissue homeostasis. PTGES is typically upregulated in response to pro-inflammatory stimuli such as cytokines (e.g., TNF-α and IL-1β) and oxidative stress, making it a key component of the inflammatory response. It is closely associated with cyclooxygenase-2 (COX-2), as both enzymes are induced during inflammation, and they work in tandem to elevate PGE2 levels. Overexpression of PTGES has been implicated in various diseases, including cancer, rheumatoid arthritis, and cardiovascular disorders, where increased PGE2 production contributes to tumor growth, immune evasion, chronic inflammation, and vascular dysfunction. PTGES is predominantly expressed in the cytoplasm and is regulated by transcriptional and post-translational mechanisms, including phosphorylation. Targeting PTGES has emerged as a potential therapeutic strategy to modulate PGE2 levels while avoiding the side effects associated with COX inhibitors, making it an area of active pharmacological research.
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