Rat Prostaglandin E Synthase, Microsomal (PTGES) CLIA Kit
845€ (96 tests)
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name
Rat Prostaglandin E Synthase, Microsomal (PTGES) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx491175
tested applications
CLIA
Description
Rat Prostaglandin E Synthase, Microsomal (PTGES) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Prostaglandin E Synthase, Microsomal (PTGES) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.115 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | MGST1L1,MPGES1,PGES,PIG12,Microsomal prostaglandin E synthase 1,p53-induced gene 12 protein,PP1294,MGST-IV,MGST1L1,TP53I12;,mPGES-1,MGST1-L1 |
| Background | CLIA Kits PTGES |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Prostaglandin E synthase (PTGES) is an inducible enzyme that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a bioactive lipid mediator involved in a wide range of physiological and pathological processes, including inflammation, fever, pain perception, and tissue homeostasis. PTGES is typically upregulated in response to pro-inflammatory stimuli such as cytokines (e.g., TNF-α and IL-1β) and oxidative stress, making it a key component of the inflammatory response. It is closely associated with cyclooxygenase-2 (COX-2), as both enzymes are induced during inflammation, and they work in tandem to elevate PGE2 levels. Overexpression of PTGES has been implicated in various diseases, including cancer, rheumatoid arthritis, and cardiovascular disorders, where increased PGE2 production contributes to tumor growth, immune evasion, chronic inflammation, and vascular dysfunction. PTGES is predominantly expressed in the cytoplasm and is regulated by transcriptional and post-translational mechanisms, including phosphorylation. Targeting PTGES has emerged as a potential therapeutic strategy to modulate PGE2 levels while avoiding the side effects associated with COX inhibitors, making it an area of active pharmacological research.
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