Rat Programmed Cell Death 1 Ligand 1 (CD274) Protein

Este producto es parte de CD274 molecule
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247€ (10 µg)

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935106861
info@markelab.com
name
Rat Programmed Cell Death 1 Ligand 1 (CD274) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166078
tested applications
WB, SDS-PAGE

Description

Rat Programmed Cell Death Protein 1 Ligand 1 is a recombinant Rat protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Programmed Cell Death 1 Ligand 1 (CD274)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 53.7 kDa  Observed MW (SDS-PAGE): 64 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser34-Val241
Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1
Background
Protein CD274
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CD274 molecule, also known as Programmed Death-Ligand 1 (PD-L1), is a critical component in the immune checkpoint pathway. Encoded by the CD274 gene located on chromosome 9p24.1, PD-L1 is primarily expressed on the surface of various cell types, including immune cells (such as T cells, B cells, dendritic cells, and macrophages) and non-immune cells (including epithelial and endothelial cells). Its expression can be upregulated in response to inflammatory signals, particularly interferon-gamma (IFN-γ). PD-L1 plays a vital role in maintaining immune homeostasis and preventing autoimmunity by regulating the activity of T cells. PD-L1 gained significant attention in cancer immunotherapy due to its role in tumor immune evasion. Many tumors exploit the PD-1/PD-L1 pathway to suppress anti-tumor immune responses, allowing cancer cells to escape immune surveillance

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