Rat Progesterone Receptor (PGR) Protein

Este producto es parte de PGR - progesterone receptor
Rat Progesterone Receptor (PGR) Protein
234€ (10 µg)

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Name
Rat Progesterone Receptor (PGR) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx068679
Tested Applications
WB, SDS-PAGE

Description

Rat Progesterone Receptor (PGR) is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Progesterone Receptor (PGR)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Gln672-Thr790
Tag: N-terminal His tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 17.3 kDa  Observed MW (SDS-PAGE): 18 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q63449
Alias
PR,NR3C3,Nuclear receptor subfamily 3 group C member 3
Background
Protein PGR
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Progesterone receptor (PGR) is a nuclear receptor that mediates the effects of progesterone, a steroid hormone involved in regulating the female reproductive system and various physiological processes PGR plays a key role in processes such as the menstrual cycle, pregnancy, and embryogenesis It functions by binding to progesterone, which activates the receptor and induces changes in gene expression that control cell differentiation, apoptosis, and immune responses During pregnancy, PGR helps maintain uterine function and supports the development of the fetus In the menstrual cycle, it helps regulate the endometrial lining, preparing it for implantation of a fertilized egg In addition, PGR is involved in the regulation of breast tissue, where its activation is essential for mammary gland development and function Dysregulation of PGR signaling has been associated with various diseases, including hormone-driven cancers like breast cancer and endometrial cancer, where altered progesterone signaling contributes to tumor growth and progression PGR is also a target for therapies such as progestins used in birth control and hormone replacement therapies

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