Rat Progesterone Receptor (PGR) Protein

Product specifications

Proteins and Peptides

Progesterone Receptor (PGR)

E. coli

Rat

Unconjugated

Molecular Weight: Calculated MW: 17.3 kDa  Observed MW (SDS-PAGE): 18 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Gln672-Thr790

Tag: N-terminal His tag

Recombinant

> 90%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q63449

PR,NR3C3,Nuclear receptor subfamily 3 group C member 3

Protein PGR

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Progesterone receptor (PGR) is a nuclear receptor that mediates the effects of progesterone, a steroid hormone involved in regulating the female reproductive system and various physiological processes PGR plays a key role in processes such as the menstrual cycle, pregnancy, and embryogenesis It functions by binding to progesterone, which activates the receptor and induces changes in gene expression that control cell differentiation, apoptosis, and immune responses During pregnancy, PGR helps maintain uterine function and supports the development of the fetus In the menstrual cycle, it helps regulate the endometrial lining, preparing it for implantation of a fertilized egg In addition, PGR is involved in the regulation of breast tissue, where its activation is essential for mammary gland development and function Dysregulation of PGR signaling has been associated with various diseases, including hormone-driven cancers like breast cancer and endometrial cancer, where altered progesterone signaling contributes to tumor growth and progression PGR is also a target for therapies such as progestins used in birth control and hormone replacement therapies

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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

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