Rat Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ALOX15B
proveedor
Abbexareference
abx167673Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Arachidonate-15-Lipoxygenase, Type B Protein is a recombinant Rat protein expressed in E. coli.
Background
ALOX15B, a close homolog of ALOX15, catalyzes the formation of 15(S)-HETE from arachidonic acid and other polyunsaturated fatty acids. Unlike ALOX15, ALOX15B is highly expressed in epithelial tissues, including the prostate, lung, and skin, where it plays a role in maintaining cellular homeostasis, inflammation resolution, and lipid metabolism. ALOX15B-derived lipid mediators regulate anti-inflammatory responses and oxidative stress, contributing to tissue repair and barrier function. Its dysregulation has been implicated in prostate cancer, where altered ALOX15B expression promotes cell proliferation, survival, and tumor progression through lipid signaling pathways. In addition, ALOX15B has a role in metabolic diseases, such as obesity and diabetes, where it influences lipid signaling and insulin sensitivity. ALOX15B’s ability to modulate inflammatory pathways and lipid homeostasis makes it a potential therapeutic target for cancer, metabolic disorders, and inflammatory diseases.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 35.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp349-Val633 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ALOX15B
dry ice
No
availability
Shipped within 5-7 working days.
alias
15-lipoxygenase 2,Arachidonate 15-lipoxygenase B
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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