Rat Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Protein
234€ (10 µg)
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Name
Rat Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167673
Tested Applications
WB, SDS-PAGE
Description
Rat Arachidonate-15-Lipoxygenase, Type B Protein is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Asp349-Val633 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 35.8 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8K4F2 |
| Alias | 15-lipoxygenase 2,Arachidonate 15-lipoxygenase B |
| Background | Protein ALOX15B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
ALOX15B, a close homolog of ALOX15, catalyzes the formation of 15(S)-HETE from arachidonic acid and other polyunsaturated fatty acids. Unlike ALOX15, ALOX15B is highly expressed in epithelial tissues, including the prostate, lung, and skin, where it plays a role in maintaining cellular homeostasis, inflammation resolution, and lipid metabolism. ALOX15B-derived lipid mediators regulate anti-inflammatory responses and oxidative stress, contributing to tissue repair and barrier function. Its dysregulation has been implicated in prostate cancer, where altered ALOX15B expression promotes cell proliferation, survival, and tumor progression through lipid signaling pathways. In addition, ALOX15B has a role in metabolic diseases, such as obesity and diabetes, where it influences lipid signaling and insulin sensitivity. ALOX15B’s ability to modulate inflammatory pathways and lipid homeostasis makes it a potential therapeutic target for cancer, metabolic disorders, and inflammatory diseases.
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