Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Antibody
312€ (60 µl)
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935106861
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name
Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005232
tested applications
WB, IF/ICC
Description
ALOX15B Antibody is a Rabbit Polyclonal antibody against ALOX15B. This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15B (ALOX15B) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15296 |
| Gene ID | 247 |
| NCBI Accession | NP_001132.2 |
| Alias | 15-lipoxygenase 2,Arachidonate 15-lipoxygenase B |
| Background | Antibody anti-ALOX15B |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ALOX15B, a close homolog of ALOX15, catalyzes the formation of 15(S)-HETE from arachidonic acid and other polyunsaturated fatty acids. Unlike ALOX15, ALOX15B is highly expressed in epithelial tissues, including the prostate, lung, and skin, where it plays a role in maintaining cellular homeostasis, inflammation resolution, and lipid metabolism. ALOX15B-derived lipid mediators regulate anti-inflammatory responses and oxidative stress, contributing to tissue repair and barrier function. Its dysregulation has been implicated in prostate cancer, where altered ALOX15B expression promotes cell proliferation, survival, and tumor progression through lipid signaling pathways. In addition, ALOX15B has a role in metabolic diseases, such as obesity and diabetes, where it influences lipid signaling and insulin sensitivity. ALOX15B’s ability to modulate inflammatory pathways and lipid homeostasis makes it a potential therapeutic target for cancer, metabolic disorders, and inflammatory diseases.
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In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating(ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes(ALOX15, ALOX15B). ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms.(PMID:24373925). ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa.
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