Rat Platelet-activating factor receptor (PTAFR) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Rat Platelet-activating factor receptor (PTAFR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx391831
tested applications
ELISA
Description
Rat Platelet-activating factor receptor (PTAFR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat PTAFR concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Platelet-activating factor receptor (PTAFR) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P46002 |
| Gene ID | 58949 |
| Alias | PTAFR,PAFr,AGEPC receptor |
| Background | Elisa kits for PTAFR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PTAFR is a G protein-coupled receptor activated by platelet-activating factor (PAF), a potent phospholipid mediator involved in inflammation, immune responses, and thrombosis. PTAFR is widely expressed on platelets, endothelial cells, leukocytes, and in various tissues, where it mediates diverse inflammatory and immune responses. Upon activation, PTAFR couples to Gq and Gi proteins, leading to calcium mobilization, activation of phospholipase C (PLC), and downstream signaling pathways that promote chemotaxis, cytokine release, and oxidative stress. PTAFR plays a central role in allergic reactions, asthma, cardiovascular dysfunction, and sepsis by amplifying inflammatory cascades and vascular permeability. Dysregulation of PTAFR is associated with chronic inflammatory diseases, ischemic injuries, and immune-related conditions. PTAFR antagonists are being explored as potential therapeutics for asthma, sepsis, and cardiovascular diseases by suppressing excessive PAF-mediated inflammation and thrombosis. Its involvement in inflammation and vascular responses positions PTAFR as a critical target for treating immune and inflammatory disorders.
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