Rat PHD finger protein 11-like (PHF11L) ELISA Kit

Background

PHD Finger Protein 11 like (PHF11L) is a member of the PHD finger protein family, characterized by the presence of a PHD zinc finger domain, which is commonly involved in chromatin-mediated transcriptional regulation and epigenetic modification. It plays a significant role in modulating immune responses by regulating gene expression related to lymphocyte activation, proliferation, and differentiation. PHF11L has been implicated in transcriptional activation of cytokine genes and is particularly associated with enhanced expression of Th2 cytokines like IL-4 and IL-13, influencing allergic responses and asthma susceptibility. It also interacts with chromatin remodeling complexes, suggesting its role in modifying histone marks to regulate access to transcriptional machinery. Dysregulation or mutations in PHF11L have been linked to inflammatory diseases and autoimmune disorders, underscoring its role in maintaining immune homeostasis. Furthermore, PHF11L expression is modulated by environmental stimuli and signaling pathways, indicating its dynamic role in immune cell function and response to external cues. Emerging evidence suggests that PHF11L may also participate in cancer biology, with studies exploring its involvement in regulating genes associated with cell cycle and DNA repair, though its precise contributions to tumorigenesis require further investigation.