Rat Parathyroid Hormone Receptor 1 (PTH1R) ELISA Kit

Este producto es parte de PTHR - Parathyroid Hormone Receptor
Rat Parathyroid Hormone Receptor 1 (PTH1R) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for PTH1R

proveedor

Abbexa

reference

abx391777

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Parathyroid Hormone Receptor 1 (PTH1R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat PTH1R concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.

Características del producto

category

ELISA Kits


immunogen target

Parathyroid Hormone Receptor 1 (PTH1R)


reactivity

Rat


test range

78 pg/ml - 5000 pg/ml


sensitivity

< 46.9 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PTH1R,PPR,PTHR,PTHR1,EKNS, PFE


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

PTH1R


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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