Parathyroid Hormone Receptor 1 (PTH1R) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Parathyroid Hormone Receptor 1 (PTH1R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001452
tested applications
WB, IHC
Description
PTH1R Antibody is a Rabbit Polyclonal antibody against PTH1R. The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Parathyroid Hormone Receptor 1 (PTH1R) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03431 |
| Gene ID | 5745 |
| NCBI Accession | NP_000307.1 |
| Alias | PTH1R,PPR,PTHR,PTHR1,EKNS, PFE |
| Background | Antibody anti-PTH1R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PTH1R is a G protein-coupled receptor activated by parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). It is primarily expressed in bone, kidney, and cartilage, where it regulates calcium and phosphate homeostasis, bone remodeling, and cartilage development. PTH1R couples to both Gs and Gq proteins, leading to activation of adenylate cyclase (increasing cAMP) and phospholipase C (PLC) pathways. In bone, PTH1R mediates osteoblast activation, enhancing bone formation and resorption in response to PTH. In the kidney, PTH1R regulates calcium reabsorption and phosphate excretion to maintain calcium balance. Dysregulation of PTH1R signaling is associated with hyperparathyroidism, hypoparathyroidism, and bone diseases like osteoporosis. PTH analogs that target PTH1R are used therapeutically to treat osteoporosis and hypoparathyroidism by promoting bone growth and mineral homeostasis. PTH1R’s essential role in calcium regulation and skeletal health makes it a key target for metabolic bone diseases.
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