Rat Glucocorticoid Receptor (NR3C1) Protein
2626€ (1 mg)
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935106861
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name
Rat Glucocorticoid Receptor (NR3C1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068343
tested applications
WB, SDS-PAGE
Description
Recombinant Glucocorticoid Receptor (NR3C1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glucocorticoid Receptor (NR3C1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 12.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser106-Thr211 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06536 |
| Alias | GR,GCR,GRL,GCCR,GCRST,Glucocorticoid receptor |
| Background | Protein NR3C1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Nuclear receptor subfamily 3 group C member 1 (NR3C1), also known as the glucocorticoid receptor (GR), is a nuclear receptor that mediates the effects of glucocorticoids, hormones involved in stress response, metabolism, and immune function NR3C1 is activated by glucocorticoids, such as cortisol, and regulates the expression of genes involved in inflammation, immune suppression, and metabolism It is expressed in a variety of tissues, including the liver, immune cells, and brain, where it influences processes such as glucose metabolism, fat storage, and the immune response NR3C1 plays a key role in the body’s response to stress by regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the production of cortisol and other stress hormones Dysregulation of NR3C1 signaling has been linked to various diseases, including metabolic syndrome, depression, autoimmune disorders, and cancer, where improper glucocorticoid signaling can contribute to inflammation, altered metabolism, and immune dysfunction GR is also a target for corticosteroid drugs used to treat conditions like asthma, arthritis, and autoimmune diseases
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