Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Antibody
383.5€ (100 µl)
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name
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx011844
tested applications
ELISA, WB, IHC, IF/ICC, FCM
Description
The protein encoded by this gene is a receptor for glucocorticoids and can act as both a transcription factor and a regulator of other transcription factors. The encoded protein can bind DNA as a homodimer or as a heterodimer with another protein such as the retinoid X receptor. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | M509 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04150 |
| Gene ID | 2908 |
| OMIM | 138040 |
| Alias | GR,GCR,GRL,GCCR,GCRST,Glucocorticoid receptor |
| Background | Antibody anti-NR3C1 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
Nuclear receptor subfamily 3 group C member 1 (NR3C1), also known as the glucocorticoid receptor (GR), is a nuclear receptor that mediates the effects of glucocorticoids, hormones involved in stress response, metabolism, and immune function NR3C1 is activated by glucocorticoids, such as cortisol, and regulates the expression of genes involved in inflammation, immune suppression, and metabolism It is expressed in a variety of tissues, including the liver, immune cells, and brain, where it influences processes such as glucose metabolism, fat storage, and the immune response NR3C1 plays a key role in the body’s response to stress by regulating the hypothalamic-pituitary-adrenal (HPA) axis, which controls the production of cortisol and other stress hormones Dysregulation of NR3C1 signaling has been linked to various diseases, including metabolic syndrome, depression, autoimmune disorders, and cancer, where improper glucocorticoid signaling can contribute to inflammation, altered metabolism, and immune dysfunction GR is also a target for corticosteroid drugs used to treat conditions like asthma, arthritis, and autoimmune diseases
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