Rat Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) Protein

Este producto es parte de NR0B - nuclear receptor subfamily 0 group B member
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234€ (10 µg)

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935106861
info@markelab.com
name
Rat Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650555
tested applications
WB, SDS-PAGE

Description

Rat NR0B1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 28.4 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Ala227
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P70503
Alias
AHC,AHX,DSS,GTD,HHG,AHCH,DAX1,DAX-1,NROB1,SRXY2,Nuclear receptor DAX-1,DSS-AHC critical region on the X chromosome protein 1
Background
Protein NR0B1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Nuclear receptor subfamily 0 group B member 1 (NR0B1), also known as DAX-1, is a nuclear receptor that plays a crucial role in the regulation of endocrine function, particularly in the development and function of the gonads and adrenal glands NR0B1 acts as a transcriptional regulator by binding to DNA and influencing the expression of target genes involved in steroidogenesis, sexual differentiation, and reproductive function It functions primarily by repressing the activity of other nuclear receptors, such as steroid hormone receptors, and plays a key role in controlling the balance of sex hormones and their effects on the body NR0B1 is essential for the proper development of the hypothalamic-pituitary-gonadal axis, and mutations in the NR0B1 gene have been associated with disorders such as 46, XY gonadal dysgenesis, a condition that results in underdeveloped gonads and infertility Additionally, NR0B1 is involved in regulating the development of the central nervous system and the regulation of bone metabolism Dysregulation of NR0B1 has been linked to several endocrine disorders and cancers

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