Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) Antibody
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Description
Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) Antibody is a Rabbit Polyclonal antibody against Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nuclear Receptor Subfamily 0, Group B, Member 1 (NR0B1) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AHC,AHX,DSS,GTD,HHG,AHCH,DAX1,DAX-1,NROB1,SRXY2,Nuclear receptor DAX-1,DSS-AHC critical region on the X chromosome protein 1 |
| Background | Antibody anti-NR0B1 |
| Status | RUO |
Descripción
Nuclear receptor subfamily 0 group B member 1 (NR0B1), also known as DAX-1, is a nuclear receptor that plays a crucial role in the regulation of endocrine function, particularly in the development and function of the gonads and adrenal glands NR0B1 acts as a transcriptional regulator by binding to DNA and influencing the expression of target genes involved in steroidogenesis, sexual differentiation, and reproductive function It functions primarily by repressing the activity of other nuclear receptors, such as steroid hormone receptors, and plays a key role in controlling the balance of sex hormones and their effects on the body NR0B1 is essential for the proper development of the hypothalamic-pituitary-gonadal axis, and mutations in the NR0B1 gene have been associated with disorders such as 46, XY gonadal dysgenesis, a condition that results in underdeveloped gonads and infertility Additionally, NR0B1 is involved in regulating the development of the central nervous system and the regulation of bone metabolism Dysregulation of NR0B1 has been linked to several endocrine disorders and cancers
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