Rat NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) ELISA Kit
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Description
Rat NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat E3 SUMO-protein ligase NSE2 concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q4V8A0 |
| Background | Elisa kits for NSMCE2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
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NSMCE2 antibody
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
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NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) Antibody
NSMCE2 Antibody is a Rabbit Polyclonal against NSMCE2.
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NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) Antibody
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