NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) Antibody
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Description
NSMCE2 Antibody is a Rabbit Polyclonal against NSMCE2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96MF7 |
| Gene ID | 286053 |
| OMIM | 617246 |
| Background | Antibody anti-NSMCE2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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NSMCE2 antibody
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
Ver Producto
NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) Antibody
NSMCE2 Antibody is a Rabbit Polyclonal against NSMCE2.
Ver Producto
NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase (NSMCE2) Antibody
NSMCE2 Antibody is a Rabbit Polyclonal against NSMCE2.
Ver Producto