Rat Noggin (NOG) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein NOG
proveedor
Abbexareference
abx068319Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Noggin (NOG) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Noggin (NOG) is a secreted glycoprotein that plays a critical role in regulating embryonic development and tissue homeostasis. It functions as an antagonist of bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-β) superfamily. By binding directly to BMPs such as BMP-2, BMP-4, and BMP-7, Noggin inhibits their ability to interact with receptors on the cell surface, thereby preventing the activation of downstream signaling pathways. This modulation is essential for proper skeletal development, including joint formation and bone growth, as well as the differentiation of neural and mesenchymal tissues. Noggin is expressed in various embryonic structures, including the notochord and somites, and its spatial and temporal expression is tightly regulated to ensure normal development. Mutations or dysregulation of NOG can result in skeletal disorders such as symphalangism and multiple synostoses syndrome. Noggin has also been implicated in processes like wound healing, cancer, and fibrosis, where BMP signaling plays a role. As a therapeutic target, Noggin's ability to modulate BMP activity makes it a potential candidate for treating conditions like osteoporosis and fibrodysplasia ossificans progressiva (FOP). Its role in tissue engineering and regenerative medicine is also being explored.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Noggin (NOG)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 43.7 kDa Observed MW: 44 kDa (determined by SDS-PAGE) Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met28-Cys144 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NOG
dry ice
No
availability
Shipped within 5-7 working days.
alias
SYM1, SYNS1,SYNS1A
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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