Human NOG (Noggin) ELISA Kit

Este producto es parte de NOG - Noggin
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935106861
info@markelab.com
name
Human NOG (Noggin) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH1051
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Human
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
Q13253
Alias
SYM1, SYNS1,SYNS1A
Background
Elisa kits for NOG
Status
RUO

Noggin (NOG) is a secreted glycoprotein that plays a critical role in regulating embryonic development and tissue homeostasis. It functions as an antagonist of bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-β) superfamily. By binding directly to BMPs such as BMP-2, BMP-4, and BMP-7, Noggin inhibits their ability to interact with receptors on the cell surface, thereby preventing the activation of downstream signaling pathways. This modulation is essential for proper skeletal development, including joint formation and bone growth, as well as the differentiation of neural and mesenchymal tissues. Noggin is expressed in various embryonic structures, including the notochord and somites, and its spatial and temporal expression is tightly regulated to ensure normal development. Mutations or dysregulation of NOG can result in skeletal disorders such as symphalangism and multiple synostoses syndrome. Noggin has also been implicated in processes like wound healing, cancer, and fibrosis, where BMP signaling plays a role. As a therapeutic target, Noggin's ability to modulate BMP activity makes it a potential candidate for treating conditions like osteoporosis and fibrodysplasia ossificans progressiva (FOP). Its role in tissue engineering and regenerative medicine is also being explored.

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