Rat Nitric Oxide Synthase, Inducible (NOS2) Protein

Este producto es parte de NOS2 - Nitric oxide synthase 2
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234€ (10 µg)

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935106861
info@markelab.com
name
Rat Nitric Oxide Synthase, Inducible (NOS2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167691
tested applications
WB, SDS-PAGE

Description

NOS2 Protein is a recombinant Rat protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Nitric Oxide Synthase, Inducible (NOS2)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 19.6 kDa  Observed MW (SDS-PAGE): 19 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met530-Lys693
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q06518
Alias
Inosl,Macrophage NOS,MAC-NOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2,NOS2A
Background
Protein NOS2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

NOS2, also known as inducible nitric oxide synthase (iNOS), is an enzyme responsible for the production of nitric oxide (NO), a key signaling molecule involved in immune defense, inflammation, and vasodilation NOS2 is primarily expressed in macrophages, neutrophils, and other immune cells upon stimulation by pro-inflammatory cytokines like IFN-γ, TNF-α, or microbial components such as lipopolysaccharide (LPS) NOS2-derived NO plays a critical role in host defense by killing pathogens, including bacteria, fungi, and parasites, through oxidative stress and inhibition of microbial enzymes Dysregulated NOS2 activity contributes to chronic inflammation, sepsis, and tissue damage observed in diseases such as autoimmune disorders, asthma, and neurodegeneration In cancers, NO produced by NOS2 can have dual effects, promoting tumor growth by inducing angiogenesis and suppressing immune responses or inhibiting tumor progression through cytotoxicity Regulation of NOS2 is of therapeutic interest for modulating inflammation and oxidative stress in infectious diseases, cardiovascular dysfunction, and cancer

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