Nitric Oxide Synthase Inducible Phospho-Tyr151 (NOS2 pY151) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Nitric Oxide Synthase Inducible Phospho-Tyr151 (NOS2 pY151) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012646
tested applications
ELISA, IHC
Description
Rabbit polyclonal antibody against NOS2 protein. Immunogen region is N-terminal. Specificity is as follows for the reactive species: H:Y151, M:Y145, R:Y151.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nitric Oxide Synthase Inducible Phospho-Tyr151 (NOS2 pY151) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr151 |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35228 |
| Alias | Inosl,Macrophage NOS,MAC-NOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2,NOS2A |
| Background | Antibody anti-NOS2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NOS2, also known as inducible nitric oxide synthase (iNOS), is an enzyme responsible for the production of nitric oxide (NO), a key signaling molecule involved in immune defense, inflammation, and vasodilation NOS2 is primarily expressed in macrophages, neutrophils, and other immune cells upon stimulation by pro-inflammatory cytokines like IFN-γ, TNF-α, or microbial components such as lipopolysaccharide (LPS) NOS2-derived NO plays a critical role in host defense by killing pathogens, including bacteria, fungi, and parasites, through oxidative stress and inhibition of microbial enzymes Dysregulated NOS2 activity contributes to chronic inflammation, sepsis, and tissue damage observed in diseases such as autoimmune disorders, asthma, and neurodegeneration In cancers, NO produced by NOS2 can have dual effects, promoting tumor growth by inducing angiogenesis and suppressing immune responses or inhibiting tumor progression through cytotoxicity Regulation of NOS2 is of therapeutic interest for modulating inflammation and oxidative stress in infectious diseases, cardiovascular dysfunction, and cancer
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