Rat Neuropeptide Y Receptor Y1 (NPY1R) Protein

Product specifications

Proteins and Peptides

Neuropeptide Y Receptor Y1 (NPY1R)

E. coli

Rat

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

NPY1R,NPY1-R,NPYR,NPY-Y1 receptor,FC5,neuropeptide Y receptor type 1,Y1-R

Protein NPY1R

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

NPY1R is a G protein-coupled receptor activated by neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). It is predominantly expressed in the central nervous system (CNS), particularly in the hypothalamus, as well as peripheral tissues, where it regulates appetite, energy homeostasis, and cardiovascular function. NPY1R couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating calcium and potassium channels. Activation of NPY1R stimulates feeding behavior and reduces energy expenditure, contributing to weight gain and energy conservation. NPY1R is also involved in regulating stress responses, anxiety, and blood pressure. Dysregulation of NPY1R signaling is linked to obesity, metabolic disorders, and cardiovascular dysfunction. NPY1R antagonists are being explored as potential therapeutics for obesity and metabolic syndrome, as blocking NPY1R can reduce food intake and promote weight loss. Additionally, NPY1R modulators are being investigated for anxiety and stress-related conditions due to its role in emotional regulation.

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